Monthly Archives: January 2021

Moon phase and sleep correlation is not quite a sine wave

Casiraghi et al. (2021) in Science Advances (DOI: 10.1126/sciadv.abe0465) show that human sleep duration and onset depends on the phase of the moon. Their interpretation is that light availability during the night caused humans to adapt their sleep over evolutionary time. Casiraghi et al. fit a sine curve to both sleep duration and onset as functions of the day in the monthly lunar cycle, but their Figure 1 A, B for the full sample and the blue and orange curves for the rural groups in Figure 1 C, D show a statistically significant deviation from a sine function. Instead of same-sized symmetric peaks and troughs, sleep duration has two peaks with a small trough between, then a large sharp trough which falls more steeply than rises, then two peaks again. Sleep onset has a vertically reflected version of this pattern. These features are statistically significant, based on the confidence bands Casiraghi and coauthors have drawn in Figure 1.

The significant departure of sleep patterns from a sine wave calls into question the interpretation that light availability over evolutionary time caused these patterns. What fits the interpretation of Casiraghi et al. is that sleep duration is shortest right before full moon, but what does not fit is that the duration is longest right after full and new moons, but shorter during a waning crescent moon between these.

It would better summarise the data to use the first four terms of a Fourier series instead of just the first term. There seems little danger of overfitting, given N=69 and t>60.

A questionable choice of the authors is to plot the sleep duration and onset of only the 35 best-fitting participants in Figure 2. A more honest choice yielding the same number of plots would pick every other participant in the ranking from the best fit to the worst.

In the section Materials and Methods, Casiraghi et al. fitted both a 15-day and a 30-day cycle to test for the effect of the Moon’s gravitational pull on sleep. The 15-day component was weaker in urban communities than rural, but any effect of gravity should be the same in both. By contrast, the effect of moonlight should be weaker in urban communities, but the urban community data (Figure 1 C, D green curve) fits a simple sine curve better than rural. It seems strange that sleep in urban communities would correlate more strongly with the amount of moonlight, like Figure 1 shows.

Clinical trials of other drugs in other species to predict a drug’s effect in humans

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Suppose we want to know whether a drug is safe or effective for humans, but do not have data on what it does in humans, only on its effects in mice, rats, rhesus macaques and chimpanzees. In general, we can predict the effect of the drug on humans better with the animal data than without it. Information on “nearby” realisations of a random variable (effect of the drug) helps predict the realisation we are interested in. The method should weight nearby observations more than observations further away when predicting. For example, if the drug has a positive effect in animals, then predicts a positive effect in humans, and the larger the effect in animals, the greater the predicted effect in humans.

A limitation of weighting is that it does not take into account the slope of the effect when moving from further observations to nearer. For example, a very large effect of the drug in mice and rats but a small effect in macaques and chimpanzees predicts the same effect in humans as a small effect in rodents and a large one in monkeys and apes, if the weighted average effect across animals is the same in both cases. However, intuitively, the first case should have a smaller predicted effect in humans than the second, because moving to animals more similar to humans, the effect becomes smaller in the first case but larger in the second. The idea is similar to a proportional integral-derivative (PID) controller in engineering.

The slope of the effect of the drug is extra information that increases the predictive power of the method if the assumption that the similarity of effects decreases in genetic distance holds. Of course, if this assumption fails in the data, then imposing it may result in bias.

Assumptions may be imposed on the method using constrained estimation. One constraint is the monotonicity of the effect in some measure of distance between observations. The method may allow for varying weights by adding interaction terms (e.g., the effect of the drug times genetic similarity). The interaction terms unfortunately require more data to estimate.

Extraneous information about the slope of the effect helps justify the constraints and reduces the need for adding interaction terms, thus decreases the data requirement. An example of such extra information is whether the effects of other drugs that have been tested in these animals as well as humans were monotone in genetic distance. Using information about these other drugs imposes the assumption that the slopes of the effects of different drugs are similar. The similarity of the slopes should intuitively depend on the chemical similarity of the drugs, with more distant drugs having more different profiles of effects across animals.

The similarity of species in terms of the effects drugs have on them need not correspond to genetic similarity or the closeness of any other observable characteristic of these organisms, although often these similarities are similar. The similarity of interest is how similar the effects of the drug are across these species. Estimating this similarity based on the similarity of other drugs across these animals may also be done by a weighted regression, perhaps with constraints or added interaction terms. More power for the estimation may be obtained from simultaneous estimation of the drug-effect-similarity of the species and the effect of the drug in humans. An analogy is demand and supply estimation in industrial organisation where observations about each side of the market give information about the other side. Another analogy is duality in mathematics, in this case between the drug-effect-similarity of the species and the given drug’s similarity of effects across these species.

The similarity of drugs in terms of their effects on each species need not correspond to chemical similarity, although it often does. The similarity of interest for the drugs is how similar their effects are in humans, and also in other species.

The inputs into the joint estimation of drug similarity, species similarity and the effect of the given drug in humans are the genetic similarity of the species, the chemical similarity of the drugs and the effects for all drug-species pairs that have been tested. In the matrix where the rows are the drugs and the columns the species, we are interested in filling in the cell in the row “drug of interest” and the column “human”. The values in all the other cells are informative about this cell. In other words, there is a benefit from filling in these other cells of the matrix.

Given the duality of drugs and species in the drug effect matrix, there is information to be gained from running clinical trials of chemically similar human-use-approved drugs in species in which the drug of interest has been tested but the chemically similar ones have not. The information is directly about the drug-effect-similarity of these species to humans, which indirectly helps predict the effect of the drug of interest in humans from the effects of it in other species. In summary, testing other drugs in other species is informative about what a given drug does in humans. Adapting methods from supply and demand estimation, or otherwise combining all the data in a principled theoretical framework, may increase the information gain from these other clinical trials.

Extending the reasoning, each (species, drug) pair has some unknown similarity to the (human, drug of interest) pair. A weighted method to predict the effect in the (human, drug of interest) pair may gain power from constraints that the similarity of different (species, drug) pairs increases in the genetic closeness of the species and the chemical closeness of the drugs.

Define Y_{sd} as the effect of drug d in species s. Define X_{si} as the observable characteristic (gene) i of species s. Define X_{dj} as the observable characteristic (chemical property) j of drug d. The simplest method is to regress Y_{sd} on all the X_{si} and X_{dj} and use the coefficients to predict the Y_{sd} of the (human, drug of interest) pair. If there are many characteristics i and j and few observations Y_{sd}, then variable selection or regularisation is needed. Constraints may be imposed, like X_{si}=X_i for all s and X_{dj}=X_j for all d.

Fused LASSO (least absolute shrinkage and selection operator), clustered LASSO and prior LASSO seem related to the above method.

Leader turnover due to organisation performance is underestimated

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Berry and Fowler (2021) “Leadership or luck? Randomization inference for leader effects in politics, business, and sports” in Science Advances propose a method they call RIFLE for testing the null hypothesis that leaders have no effect on organisation performance. The method is robust to serial correlation in outcomes and leaders, but not to endogenous leader turnover, as Berry and Fowler honestly point out. The endogeneity is that the organisation’s performance influences the probability that the leader is replaced (economic growth causes voters to keep a politician in office, losing games causes a team to replace its coach).

To test whether such endogeneity is a significant problem for their results, Berry and Fowler regress the turnover probability on various measures of organisational performance. They find small effects, but this underestimates the endogeneity problem, because Berry and Fowler use linear regression, forcing the effect of performance on turnover to be monotone and linear.

If leader turnover is increased by both success (get a better job elsewhere if the organisation performs well, so quit voluntarily) and failure (fired for the organisation’s bad performance), then the relationship between turnover and performance is U-shaped. Average leaders keep their jobs, bad and good ones transition elsewhere. This is related to the Peter Principle that an employee is promoted to her or his level of incompetence. A linear regression finds a near-zero effect of performance on turnover in this case even if the true effect is large. How close the regression coefficient is to zero depends on how symmetric the effects of good and bad performance on leader transition are, not how large these effects are.

The problem for the RIFLE method of Berry and Fowler is that the small apparent effect of organisation performance on leader turnover from OLS regression misses the endogeneity in leader transitions. Such endogeneity biases RIFLE, as Berry and Fowler admit in their paper.

The endogeneity may explain why Berry and Fowler find stronger leader effects in sports (coaches in various US sports) than in business (CEOs) and politics (mayors, governors, heads of government). A sports coach may experience more asymmetry in the transition probabilities for good and bad performance than a politician. For example, if the teams fire coaches after bad performance much more frequently than poach coaches from well-performing competing teams, then the effect of performance on turnover is close to monotone: bad performance causes firing. OLS discovers this monotone effect. On the other hand, if politicians move with equal likelihood after exceptionally good and bad performance of the administrative units they lead, then linear regression finds no effect of performance on turnover. This misses the bias in RIFLE, which without the bias might show a large leader effect in politics also.

The unreasonably large effect of governors on crime (the governor effect explains 18-20% of the variation in both property and violent crime) and the difference between the zero effect of mayors on crime and the large effect of governors that Berry and Fowler find makes me suspect something is wrong with that particular analysis in their paper. In a checks-and-balances system, the governor should not have that large of influence on the state’s crime. A mayor works more closely with the local police, so would be expected to have more influence on crime.

Reduce temptation by blocking images

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Web shops try to tempt customers into unnecessary and even harmful purchases, including grocery and food ordering sites which promote unhealthy meals. The temptation can be reduced by blocking images on shopping websites. I find it useful when ordering food. Similarly, Facebook and news sites try to tempt viewers with clickbait and ads. To reduce my time-wasting, I make the clickbait less attractive by blocking images. The pictures in most news stories do not contribute any information – a story about a firm has a photo of the main building or logo of the firm or the face of its CEO, a “world leaders react to x” story has pictures of said leaders.

The blocking may require a browser extension (“block images”) and each browser and version has a little different steps for this.

In Chromium on 20 Jan 2021, no extension is needed:

1) click the three vertical dots at the top right,

2) click Settings to go to chrome://settings/,

3) scroll down to Site settings, click it,

4) scroll down to Images, click it.

5) Click the Add button to the right of the Block heading. A dialog pops up to enter a web address.

6) Copy the url of the site on which you want to block pictures, for example https://webshop.com into the Site field.

If seeing the images is necessary for some reason, then re-enable images on the website: follow steps 1-4 above, then click the three vertical dots under the Add button under the Block heading. A menu of three options pops up. Click the Allow option.

Alternatively, you may block all images on all websites and then allow only specific sites to show images. For this, follow steps 1-4 above, then click the blue button to the right of the Allow all (recommended) heading. Then click the Add button next to Allow. A dialog pops up to enter a web address. Copy the url of the site on which you want to block pictures, for example https://webshop.com into the Site field.

Dilution effect explained by signalling

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Signalling confidence in one’s arguments explains the dilution effect in marketing and persuasion. The dilution effect is that the audience averages the strength of a persuader’s arguments instead of adding the strengths. More arguments in favour of a position should intuitively increase the confidence in the correctness of this position, but empirically, adding weak arguments reduces people’s belief, which is why drug advertisements on US late-night TV list mild side effects in addition to serious ones. The target audience of these ads worries less about side effects when the ad mentions more slight problems with the drug, although additional side effects, whether weak or strong, should make the drug worse.

A persuader who believes her first argument to be strong enough to convince everyone does not waste valuable time to add other arguments. Listeners evaluate arguments partly by the confidence they believe the speaker has in these claims. This is rational Bayesian updating because a speaker’s conviction in the correctness of what she says is positively correlated with the actual validity of the claims.

A countervailing effect is that a speaker with many arguments has spent significant time studying the issue, so knows more precisely what the correct action is. If the listeners believe the bias of the persuader to be small or against the action that the arguments favour, then the audience should rationally believe a better-informed speaker more.

An effect in the same direction as dilution is that a speaker with many arguments in favour of a choice strongly prefers the listeners to choose it, i.e. is more biased. Then the listeners should respond less to the persuader’s effort. In the limit when the speaker’s only goal is always for the audience to comply, at any time cost of persuasion, then the listeners should ignore the speaker because a constant signal carries no information.

Modelling

Start with the standard model of signalling by information provision and then add countersignalling.

The listeners choose either to do what the persuader wants or not. The persuader receives a benefit B if the listeners comply, otherwise receives zero.

The persuader always presents her first argument, otherwise reveals that she has no arguments, which ends the game with the listeners not doing what the persuader wants. The persuader chooses whether to spend time at cost c>0, c<B to present her second argument, which may be strong or weak. The persuader knows the strength of the second argument but the listeners only have the common prior belief that the probability of a strong second argument is p0. If the second argument is strong, then the persuader is confident, otherwise not.

If the persuader does not present the second argument, then the listeners receive an exogenous private signal in {1,0} about the persuader’s confidence, e.g. via her subconscious body language. The probabilities of the signals are Pr(1|confident) =Pr(0|not) =q >1/2. If the persuader presents the second argument, then the listeners learn the confidence with certainty and can ignore any signals about it. Denote by p1 the updated probability that the audience puts on the second argument being strong.

If the speaker presents a strong second argument, then p1=1, if the speaker presents a weak argument, then p1=0, if the speaker presents no second argument, then after signal 1, the audience updates their belief to p1(1) =p0*q/(p0*q +(1-p0)*(1-q)) >p0 and after signal 0, to p1(0) =p0*(1-q)/(p0*(1-q) +(1-p0)*q) <p0.

The listeners prefer to comply (take action a=1) when the second argument of the persuader is strong, otherwise prefer not to do what the persuader wants (action a=0). At the prior belief p0, the listeners prefer not to comply. Therefore a persuader with a strong second argument chooses max{B*1-c, q*B*1 +(1-q)*B*0} and presents the argument iff (1-q)*B >c. A persuader with a weak argument chooses max{B*0-c, (1-q)*B*1 +q*B*0}, always not to present the argument. If a confident persuader chooses not to present the argument, then the listeners use the exogenous signal, otherwise use the choice of presentation to infer the type of the persuader.

One extension is that presenting the argument still leaves some doubt about its strength.

Another extension has many argument strength levels, so each type of persuader sometimes presents the second argument, sometimes not.

In this standard model, if the second argument is presented, then always by the confident type. As is intuitive, the second argument increases the belief of the listeners that the persuader is right. Adding countersignalling partly reverses the intuition – a very confident type of the persuader knows that the first argument already reveals her great confidence, so the listeners do what the very confident persuader wants. The very confident type never presents the second argument, so if the confident type chooses to present it, then the extra argument reduces the belief of the audience in the correctness of the persuader. However, compared to the least confident type who also never presents the second argument, the confident type’s second argument increases the belief of the listeners.